Starting the Pill for the First Time

Reviewed by Usama Ali, MPharm (GPhC: 2224726). Last reviewed: April 2026.

Your pharmacist checks your medical history, recommends a pill, and posts it to you. If you start on day 1 of your period, you are protected straight away.

Most side effects settle within 2 to 3 months. The whole process takes about 10 minutes on the phone and your pill usually arrives within 1 to 3 days.

What happens before you start the pill?

Starting the contraceptive pill for the first time begins with a short clinical consultation. You do not need to see a GP. Through the NHS Pharmacy Contraception Service, a pharmacist can assess you, recommend a pill, and supply it directly.

During the consultation, your pharmacist asks about your medical history, current medications, whether you smoke, your BMI, and whether you have any conditions that might affect which pill is suitable. For the combined pill, you also need a recent blood pressure reading (taken within the last 12 months). For the mini pill, a blood pressure check is not usually required.

These checks follow the UK Medical Eligibility Criteria (UKMEC), the same framework used by GPs and sexual health clinics. The aim is to make sure the pill is safe for you before you start.

Which pill will you get?

Your pharmacist will recommend either the combined pill or the mini pill based on your health assessment. You do not need to decide before your appointment.

Combined pillMini pill
ContainsOestrogen + progestogenProgestogen only
How you take it21 days on, 7 day breakEvery day, no break
Blood pressure needed?YesNo
Age range (PCS)16 to 4916 to 54
Protected from day 1?Yes, if started on day 1 of periodYes, if started on day 1 of period
Otherwise protected after7 days2 days (desogestrel), 2 days (Slynd)
Common first-choiceMicrogynon, RigevidonCerelle, Feanolla

If you are unsure which type suits you, read our guide on which contraceptive pill is right for me. Your pharmacist will talk through the options during your consultation.

When should you start taking the pill?

The ideal time to start is on day 1 of your period (the first day of full bleeding). If you start on day 1, you are protected against pregnancy straight away, regardless of which type of pill you take.

You can start at other times in your cycle, but you will need to use condoms or avoid sex until the pill becomes effective. For the combined pill, that means 7 days. For the desogestrel mini pill, it is 2 days. Your pharmacist will tell you exactly when protection begins based on when you start.

"We always explain this on the call," says Usama Ali, MPharm (GPhC: 2224726), pharmacist at Contraception Direct. "If your pill arrives mid-cycle and you want to start straight away, that's fine. You just need to know when you're protected and when to use condoms."

How do you take the pill?

Take one pill at the same time each day. This is the single most important thing to get right. Setting a daily alarm on your phone helps. Some people take it with breakfast, others at bedtime. Pick whatever fits your routine.

For the combined pill, you usually take it for 21 days then have a 7 day break (during which you may get a withdrawal bleed). Some packs have 28 pills, where the last 7 are inactive. Either way, you take one pill every day.

For the mini pill, you take one pill every day with no break. Desogestrel pills (Cerelle, Feanolla, Zelleta) have a 12 hour late window. Slynd has 24 hours. Traditional mini pills (Noriday, Norgeston) have just 3 hours. Your pharmacist will explain the timing for your specific pill.

What happens in the first few weeks?

Starting the pill means introducing hormones your body is not used to. It is normal to notice some changes while your body adjusts. For most people, these settle within 2 to 3 months.

You might get some spotting or irregular bleeding, particularly in the first month. This does not mean the pill is not working. It is just your body getting used to the new hormone levels. Taking the pill at the same time every day can help reduce spotting.

Some people feel slightly sick in the first week or two, especially on the combined pill. Taking your pill with food or in the evening can help. If nausea continues beyond the first couple of weeks, mention it at your next review.

What side effects might you notice?

Common side effects when starting the pill include irregular bleeding or spotting, mild nausea, headaches, breast tenderness, mood changes, and bloating. Not everyone gets them. When they do occur, they are usually mild.

The FSRH combined pill guideline notes that around 1 in 5 people experience spotting in the first 3 months. This is the most common reason people worry the pill is not working, but it does not reduce effectiveness as long as you are taking it correctly.

If side effects persist beyond 3 months or are affecting your daily life, speak to your pharmacist. You do not need to put up with them. Switching to a different type or brand of pill often resolves the issue. Many people try more than one pill before finding what suits them.

When are you fully protected?

When you startCombined pillDesogestrel mini pillTraditional mini pill
Day 1 of periodProtected straight awayProtected straight awayProtected straight away
Any other dayUse condoms for 7 daysUse condoms for 2 daysUse condoms for 2 days
After childbirthDay 21 or later (not if breastfeeding in first 6 weeks)Any time from birthAny time from birth

The pill does not protect against sexually transmitted infections. If you need STI protection, use condoms as well.

What if you forget a pill?

Missing a pill is common, especially in the first few weeks while you are building the habit. What you do depends on which pill you take, how late you are, and where you are in your pack.

For a quick answer based on your specific pill, use our missed pill tool. For a full explanation of the rules, read our guide on what to do if you miss a pill.

The short version: take the missed pill as soon as you remember. If you are within your pill's late window (24 hours for the combined pill, 12 hours for desogestrel, 3 hours for traditional mini pills, 24 hours for Slynd), you are still protected. If you are outside the window, take the pill anyway and use condoms until protection is re-established.

How do you get started?

You can start the pill through your GP, a sexual health clinic, or a pharmacy through the NHS Pharmacy Contraception Service. All routes are free on the NHS.

With Contraception Direct, you book a free phone consultation with a pharmacist. The call takes about 10 minutes. If the pill is right for you, it is posted in discreet packaging and usually arrives within 1 to 3 working days. The service covers people starting the pill for the first time as well as those who need a repeat supply.

If you are not sure which pill is right for you, you do not need to decide before booking. Your pharmacist will talk through your options and recommend what suits your body and lifestyle. That is what the consultation is for.

Not sure where to start?

Book a free phone consultation with a pharmacist. They'll check what's right for you, answer your questions, and post your pill in discreet packaging.

Book your free consultation

No GP needed. No prescription charge. Takes about 10 minutes.

Frequently asked questions

When should I start taking the pill?
If you start on day 1 of your period, you are protected straight away. If you start on any other day, use condoms for the first 7 days (combined pill) or 2 days (desogestrel mini pill). Your pharmacist will tell you exactly when to start.
How long does the pill take to work?
If started on day 1 of your period, it works straight away. Otherwise, the combined pill needs 7 days to become effective and the desogestrel mini pill needs 2 days. Use condoms until then. Your pharmacist will confirm the exact timing based on your specific pill type and when you start.
Do I need a blood pressure check before starting?
For the combined pill, yes. A blood pressure reading taken within the last 12 months is required. You can use a reading from a pharmacy, GP, or home monitor. For the mini pill, a blood pressure check is not usually needed. Your pharmacist will let you know what you need before your consultation.
Can I start the pill without seeing a GP?
Yes. You can start the pill through the NHS Pharmacy Contraception Service, a sexual health clinic, or an online service like Contraception Direct. A pharmacist carries out the full clinical assessment, checks your medical history and blood pressure (for the combined pill), and supplies the pill directly.
Will I get side effects when I first start?
Some people notice mild side effects in the first 2 to 3 months, such as spotting, nausea, headaches, or breast tenderness. These usually settle as your body adjusts. If they persist or bother you after 3 months, your pharmacist can discuss switching to a different pill.
Can I start the pill at 16?
Yes. The NHS Pharmacy Contraception Service is available from age 16. The combined pill is available to ages 16 to 49 and the mini pill to ages 16 to 54 (16 to 49 for Slynd). All consultations are confidential and your pharmacist will confirm your eligibility during the call.
What if I want to stop the pill after starting?
You can stop at any time. Your natural fertility returns quickly, usually within days. If you stop mid-pack, you are no longer protected from that point. There is no medical need to finish the pack first, though some people prefer to. Speak to your pharmacist before stopping so they can advise you.
Can I start the pill if I have never had a period?
This depends on your individual situation. Your pharmacist or GP will assess whether starting the pill is appropriate for you. It is not usually prescribed before your first period. In some cases, hormonal contraception may be started before menstruation begins, but this requires assessment by a GP or specialist.

References

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