Reviewed by Usama Ali, MPharm (GPhC: 2224726). April 2026.
Yes, the combined pill can help with acne. It works by reducing androgen levels, which lowers the amount of oil your skin produces. Combined pills containing drospirenone or desogestrel tend to have the biggest effect.
The combined pill increases SHBG, which binds testosterone and makes less available to reach your skin. Some progestogens also directly block androgens on oil glands. A Cochrane review of 31 trials confirmed that combined pills reduce acne.
| Progestogen | Example pills | Androgenic activity | Acne effect |
|---|---|---|---|
| Drospirenone | Yasmin, Lucette | Anti-androgenic | Most likely to help |
| Desogestrel (in COC) | Marvelon, Gedarel | Low androgenic | Often helpful |
| Gestodene | Femodene, Femodette | Low androgenic | Often helpful |
| Levonorgestrel | Microgynon, Rigevidon | More androgenic | Can still help, less so |
Some people notice acne starting or worsening on the mini pill. Slynd (drospirenone) is the only mini pill with anti-androgenic properties and may be less likely to cause skin issues.
Most people notice improvement within 2 to 3 months. Full results can take 4 to 6 months. Skin may get slightly worse in the first few weeks before it gets better.
If the underlying cause is hormonal, acne can return when you stop the pill.
The pill works on hormonal acne from the inside. Topical treatments work on the surface. They can be used together. If acne is moderate to severe or not responding to topical treatments alone, NICE recommends considering hormonal treatment.